Statistical Learning of Biological Systems from Perturbations
May 31 to June 5, 2015
Registration and details
Advances in biotechnology have made genome-scale measurements routine, including most recent techniques for perturbing individual genes in a targeted manner. These interventional data hold the promise to infer biological networks and to move forward systems biological approaches significantly. A major challenge now is to use the vast amount of data generated from these technologies and to devise appropriate statistical models and computational inference methods. Unlike observational data, interventional data can reveal causal relationships among genes or other biomolecular entities. As such, the statistical analysis and computational integration of perturbation data is an important step towards large-scale biological system identification with abundant applications in biology and medicine.
This workshop will (i) explore recent advances and open problems in statistical learning, data integration, and causal inference of biological systems; (ii) present biomedical applications to recent genome-wide perturbation data, such as RNA interference data, obtained, for example, from cancer cells or cells infected by pathogens; and (iii) facilitate meaningful interaction between biomedical and quantitative researchers.
We are happy to announce our recent paper by Michael I Love, Wolfgang Huber and Simon Anders: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biology, 15:550 (2014).
Abstract: comparative high-throughput sequencing assays, a fundamental task is the analysis of count data, such as read counts per gene in RNA-seq, for evidence of systematic changes across experimental conditions. Small replicate numbers, discreteness, large dynamic range and the presence of outliers require a suitable statistical approach. We present DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates. This enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression. The DESeq2 package is available at Bioconductor.
On 15-16 January 2015 we are hosting the Advanced Course: R programming and development.
The course will focus on two aspects of R programming and development.
The first part will introduce object-oriented programming using R’s S3 and S4 system and describe how to define classes, generic functions and methods. It will also present how to create Bioconductor-compliant R packages and document them. The second part will focus on various advanced topics in R programming such as unit testing, debugging, profiling and calling C/C++ code. It will also describe how to write efficient and elegant code using vectorisation, parallelization, and the functional programming paradigm. Finally, creating web applications with shiny will be discussed.
These topics will be illustrated using a small real-life bioinformatic case study. Participants will produce, at the end of the course, a fully fledged Bioconductor compliant R package.
12th-13th January 2015, EMBL Heidelberg
We are proudly hosting this year’s European Bioconductor Developers’ Meeting.
The meeting is aimed at bioinformaticians, programmers and software engineers who contribute to the Bioconductor project, or are interested in developing packages for Bioconductor. The goals are to:
- foster the exchange of technical expertise,
- keep contributors up to date with the latest developments,
- coordinate any related efforts.
For details see the the event’s website.
In November 2014 two of our PhD students, Felix Klein and Paul Theodor Pyl, successfully defended their theses.