Ascona Workshop 2015

Statistical Learning of Biological Systems from Perturbations

May 31 to June 5, 2015

Registration and details

Advances in biotechnology have made genome-scale measurements routine, including most recent techniques for perturbing individual genes in a targeted manner. These interventional data hold the promise to infer biological networks and to move forward systems biological approaches significantly. A major challenge now is to use the vast amount of data generated from these technologies and to devise appropriate statistical models and computational inference methods. Unlike observational data, interventional data can reveal causal relationships among genes or other biomolecular entities. As such, the statistical analysis and computational integration of perturbation data is an important step towards large-scale biological system identification with abundant applications in biology and medicine.

This workshop will (i) explore recent advances and open problems in statistical learning, data integration, and causal inference of biological systems; (ii) present biomedical applications to recent genome-wide perturbation data, such as RNA interference data, obtained, for example, from cancer cells or cells infected by pathogens; and (iii) facilitate meaningful interaction between biomedical and quantitative researchers.