Research Group Leader and Senior Scientist, EMBL
Primary appointment: Genome Biology Unit (Heidelberg)
Secondary appointments: European Bioinformatics Institute (EBI, Cambridge) and Structural and Computational Biology Unit (Heidelberg) and at the Molecular Medicine Partnership Unit (MMPU) of EMBL and University Hospital Heidelberg.
Wolfgang studied physics at the University of Freiburg, where he obtained a PhD in theoretical physics on stochastic models of open quantum systems. He moved to California in 1998 to do postdoctoral research in cheminformatics of small, drug-like compounds at IBM Research in San Jose, California. In 2000, his interest in cancer genomics and microarray analysis led him to the German Cancer Research Centre (DKFZ) in Heidelberg. In 2004, he joined EMBL to start a research group at the European Bioinformatics Institute (EBI) in Cambridge. In 2009, he took up a position in the newly formed Genome Biology unit of EMBL in Heidelberg, and in 2011 was promoted to EMBL Senior Scientist.
Specialising in computational biology and statistics, he collaborates with leading experimental groups in genetics and cancer research on the enabling of new, computationally intensive types of experiments and studies.
Wolfgang jointly heads the MMPU group Systems Medicine of Cancer Drugs with Sascha Dietrich from the Heidelberg University Hospital. The aim of this group is to understand intra- and inter-patient heterogeneity of response to anti-cancer drugs, a major clinical and scientific challenge. The focus is to study the interaction tumour cells with their microenvironment and consequences for drug response. We employ a tightly integrated combination of experimental and computational approaches.
Wolfgang is a founding member of Bioconductor, which started in 2001 and continues to be one of the largest bioinformatics projects. He coordinates the EC H2020 network SOUND, serves on several Scientific Advisory Boards and consults for bioinformatics and pharmaceutical companies.