Computational 4D and single-cell expression analysis of animal development and regeneration

Postdoctoral project:
Ikmi and Huber groups
European Molecular Biology Laboratory
Heidelberg, Germany

A joint postdoctoral project is planned by the groups of Aissam Ikmi and Wolfgang Huber at EMBL Heidelberg to develop cutting-edge computational approaches at the intersection of developmental and regenerative biology. The goal of the project is to build an integrated ‘big-data’ based quantitative model in 4D of gene expression, cellular behaviors and mechanics of animal development and regeneration in a unique model system, the sea anemone Nematostella vectensis. This animal has extraordinary regenerative capabilities, has a translucid body plan accessible to optical observation, and is genetically well-tractable with robust tools to manipulate gene function through CRISPR/Cas9, shRNA and transgenesis.

Oral views of a developing Nematostella.

Working in a highly collaborative environment, you will use spatially resolved and single-cell omics data combined with advanced imaging to comprehensively map, model and understand multi-cellular dynamics of regeneration from injuries and of normal development, and the relationship between these two processes, under different environmental conditions and genetic perturbations.

Your primary qualification is expertise in integrative data analysis, preferably involving one or several of: ‘omics, single-cell RNA-seq, tomo-seq and microscopy. You are fluent in R and command important statistical and data analytical methods. You are driven by making biological discoveries by in-depth data analysis and modelling. Interest in mathematical modelling is a plus. The position will be jointly affiliated with the Huber (computational biology) and Ikmi (experimental techniques and model system) labs; the opportunity to design or do own experiments is optional and can be discussed.

If you are interested, please send a motivation letter and CV to Wolfgang Huber (whuber (at) embl.de) and or Aissam Ikmi (aissam.ikmi (at) embl.de).