Research Group Leader and Senior Scientist, EMBL
Wolfgang’s interests lie in computational biology and statistical computing, and comprise method development as well as biological discovery and translation into clinical research. He collaborates with leading experimental groups in genetics and cancer research on the enabling of new, computationally intensive types of experiments and studies.
Short CV: Wolfgang studied physics at the University of Freiburg, including an Erasmus year at the University of Edinburgh. He obtained a PhD in theoretical physics on stochastic models and simulation of open quantum systems. He moved to California in 1998 to do postdoctoral research in cheminformatics of small, drug-like compounds at IBM Research Almaden in San José. In 2000, his interest in cancer genomics and microarray analysis led him to the German Cancer Research Centre (DKFZ) in Heidelberg. In 2004, he joined EMBL to start a research group at its European Bioinformatics Institute (EBI) in Cambridge. In 2009, he took up a position in the newly formed Genome Biology unit of EMBL in Heidelberg, and in 2011 became EMBL Senior Scientist.
Wolfgang jointly heads the Molecular Medicine Partnership Unit (MMPU) group Systems Medicine of Cancer Drugs with Sascha Dietrich from Heidelberg University Hospital. The aim of this group is to understand intra- and inter-patient heterogeneity of response to anti-cancer drugs, a major clinical and scientific challenge. The group studies the interaction tumour cells with their microenvironment and consequences for drug response. They employ a tightly integrated combination of experimental and computational approaches.
Wolfgang is a founding member of Bioconductor, which started in 2001 and continues to be one of the largest bioinformatics projects. He coordinated the EC H2020 network SOUND (2015-18), serves on several Scientific Advisory Boards and consults for bioinformatics and pharmaceutical companies. He has authored >160 peer-reviewed publications. There is a Google Scholar page.